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Side‐effects of mixed agonist‐antagonist analgesics used in sequential anaesthesia.
Author(s) -
Devaux C,
Schoepffler P,
GauthierLafaye JP
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04708.x
Subject(s) - agonist , analgesic , antagonist , agonist antagonist , pharmacology , partial agonist , narcotic antagonists , medicine , narcotic antagonist , anesthesia , chemistry , (+) naloxone , receptor
1 Mixed agonist‐antagonist analgesics have analgesic action but also possess a range of side‐effects. 2 Narcotic antagonists do not reverse the non‐specific effects of opiates. 3 Under certain circumstances the effects of agonists and mixed agonist‐antagonists can be additive. 4 Chronic dosage of mixed agonist‐antagonists leads to a lower level of dependence than that observed with the standard narcotics. 5 Mixed agonist‐antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.