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Influence of various antihypertensive agents on lifespan of renal hypertensive rats.
Author(s) -
Horovitz ZP,
Antonaccio MJ,
Rubin B,
Panasevich RE
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04696.x
Subject(s) - captopril , hydrochlorothiazide , medicine , angiotensin converting enzyme , endocrinology , orally active , kidney , blood pressure , urology , pharmacology , diuretic , oral administration
1 Daily treatment of two‐kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin‐converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus intermittent or chronic HCTZ had the best survival rate, whereas HCTZ alone or hydrallazine did not benefically affect survival. 3 Survival rates correlated well with control of BP in these animals.