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Effect of beta‐blockers on exercise double product (systolic blood pressure x heart rate).
Author(s) -
Vukovich RA,
Foley JE,
Brown B,
Willard DA,
Buckley M,
O'Kelly D,
Fitzgerald D,
Tormey W,
Darragh A
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04687.x
Subject(s) - pindolol , oxprenolol , atenolol , nadolol , propranolol , pharmacodynamics , timolol , heart rate , pharmacology , blood pressure , medicine , beta blocker , adrenergic beta antagonists , beta (programming language) , cardiology , pharmacokinetics , surgery , heart failure , intraocular pressure , computer science , programming language
1 The effect of single oral doses of six beta‐receptor antagonists on exercise‐induced changes in double product (systolic blood pressure x heart rate) were studied in 25 human volunteers. 2 Three doses of propranolol, nadolol, oxprenolol, pindolol, timolol and atenolol were selected for study on the basis of in vivo beta‐blocking potency. 3 Although all beta‐blockers studied reduced the double product response to exercise, the pharmacodynamics of this effect differed markedly. 4 Pharmacodynamic half‐lives, estimated for the drug tested, were 39 h for nadolol, atenolol 21 h, timolol 15 h, oxprenolol 13 h, propranolol 11 and pindolol 8 h. 5 These results suggest that the clinical choice of a beta‐blocker with the least problems of compliance can be made on the basis of pharmacodynamics as well as pharmacological profile.