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Psychomotor changes during initial day of benzodiazepine medication.
Author(s) -
Wittenborn JR,
Flaherty CF,
McGough WE,
Nash RJ
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04668.x
Subject(s) - clobazam , psychomotor learning , diazepam , benzodiazepine , placebo , anesthesia , medicine , anti anxiety agents , psychology , psychiatry , anxiety , epilepsy , cognition , receptor , alternative medicine , pathology
1 The detracting psychomotor effects of diazepam (5 mg three times daily) and clobazam (an investigational 1,5‐benzodiazepine) were compared with placebo effects over the course of the initial day of medication. Tests were administered at hourly intervals and the data were analyzed from the standpoint of contrasts at each session and from the standpoint of trends that accrued during the course of the day. 2 It is concluded that among normal volunteers diazepam 5 mg three times daily may be near the threshold for detracting psychomotor consequences during the initial day and that clobazam seems to be without detracting consequences and may have some enhancing effects.