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N‐Methyl‐benzylamine, a metabolite of pargyline in man.
Author(s) -
Pirisino R,
Ciottoli GB,
Buffoni F,
Anselmi B,
Curradi C
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04648.x
Subject(s) - pargyline , benzylamine , metabolite , chemistry , urine , chromatography , excretion , pharmacology , biochemistry , organic chemistry , monoamine oxidase , biology , enzyme
1. N‐methyl‐benzylamine was identified in human urine and plasma after the administration of pargyline in man. This metabolite was identified by thin layer chromatography mobility, gas chromatographic retention time and mass spectrum relative to authentic N‐methyl‐benzylamine. 2. [14C]‐N‐methyl‐benzylamine, together with a small amount of [14C]‐ benzylamine, was formed in vitro from [14C]‐pargyline when this was incubated with human and rat liver microsomes. 3. The urinary excretion rates of pargyline and its metabolite have also been described.