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Onset and duration of beta‐adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral).
Author(s) -
Watson RD,
Littler WA
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb04642.x
Subject(s) - acebutolol , heart rate , blood pressure , placebo , medicine , dose–response relationship , anesthesia , cardiology , alternative medicine , pathology
1. The onset and duration of action of once daily acebutolol (400 mg) on resting and exercise heart rate and blood pressure were studied in normal subjects in a double‐blind, cross‐over trial against placebo. Subjects were studied 1.5, 3, 8 and 24 h after the first dose and 24 h after the fifth dose. 2. Resting and exercise heart rate and blood pressure were significantly reduced within 90 min of the first dose. 3. A significant reduction in these variables persisted throughout 24 h after the fifth daily dose. However, at 24 h the effects were considerably attenuated, the falls in resting and exercise systolic blood pressure being only 5%. 4. A linear relationship was noted between log serum drug level and percentage reduction of exercise heart rate.