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Probenecid: an unexplained effect on cephalosporin pharmacology.
Author(s) -
Welling PG,
Dean S,
Selen A,
Kendall MJ,
Wise R
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb01032.x
Subject(s) - probenecid , cefaclor , cephradine , antibiotics , pharmacology , urine , cephalosporin , urinary system , excretion , chemistry , pharmacokinetics , oral administration , medicine , biochemistry
1 The influence of probenecid on serum levels and urinary excretion of orally administered cephradine and cefaclor has been investigated. 2 Probenecid caused serum levels of both antibiotics to be increased and also prolonged. Urinary excretion of antibiotic activity was slightly but not significantly decreased by probenecid during the initial 6 h postdosing. It was significantly increased in 6‐12 h urine, but only a small percentage of the doses were excreted during that period. 3 The increased serum levels of antibiotic were greater than could be accounted for by reduced elimination rate alone. Possible mechanisms to account for increased circulating levels of antibiotic in the presence of probenecid are discussed in the light of previous observations on probenecid induced changes in tissue distribution of beta‐lactam antibiotics.