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Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration.
Author(s) -
Vermeulen NP,
Teunissen MW,
Breimer DD
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb01026.x
Subject(s) - pharmacokinetics , urine , saliva , metabolite , chemistry , oral administration , excretion , urinary system , absorption (acoustics) , endocrinology , medicine , plasma concentration , pharmacology , biochemistry , physics , acoustics
1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half‐live of 11.0 +/‐ 1.2 h (n=4). Peak levels were reached at 2.7 +/‐ 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/‐ 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/‐ 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half‐lives were slightly shorter than the corresponding plasma half‐lives.