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Gentamicin pharmacokinetics in kwashiorkor.
Author(s) -
Buchanan N,
Davis MD,
Eyberg C
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb01024.x
Subject(s) - kwashiorkor , pharmacokinetics , gentamicin , medicine , pharmacology , antibiotics , malnutrition , chemistry , biochemistry
1 Single dose intravenous gentamicin kinetics (2.4 mg/kg) were studied in six children with kwashiorkor. It was observed, that therapeutic drug concentrations were achieved which should be neither oto‐ nor nephrotoxic. 2 Due to the diminished glomerular filtration and renal plasma flow seen in the acute phase of kwashiorkor, gentamicin half‐ life was prolonged (229.0 +/‐ 94.8 min) at this time returning to normal (178.5 +/‐ 99.5 min) with nutritional rehabilitation.