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Biliary excretion of erythromycin after parenteral administration.
Author(s) -
Chelvan P,
HamiltonMiller JM,
Brumfitt W
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb01007.x
Subject(s) - erythromycin , excretion , medicine , pharmacology , drug , oral administration , antibiotics , gastroenterology , chemistry , biochemistry
1 The biliary excretion of erythromycin has been studied following parenteral administration in 23 patients. 2 Mean bile levels of the drug were approximately ten times higher than corresponding serum concentrations 1 h after i.v. (erythromycin lactobionate) and i.m. (erythromycin ethylsuccinate) injection. 3 Thus, unlike many antimicrobial agents, these compounds are well concentrated in the bile.