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Effect of aluminum hydroxide on diflunisal absorption.
Author(s) -
Verbeeck R,
Tjandramaga TB,
Mullie A,
Verbesselt R,
Schepper PJ
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00997.x
Subject(s) - diflunisal , bioavailability , urine , chemistry , absorption (acoustics) , hydroxide , oral administration , chromatography , excretion , pharmacology , pharmacokinetics , medicine , materials science , biochemistry , inorganic chemistry , composite material
1 The effect of aluminum hydroxide on the oral absorption of diflunisal was studied in healthy subjects. 2 Relative bioavailability of the oral diflunisal dose (500 mg) was estimated by comparison of the areas under plasma concentration versus time curves, and comparison of the amount of drug (unchanged + glucuronides) excreted in the urine. 3 From the AUC‐method, a relative bioavailability of 0.60 was calculated. A similar value (F = 0.63) was obtained from the urinary excretion data. 4 The results indicate that co‐administration of aluminum hydroxide reduces the bioavailability of oral diflusinal by about 40%.