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Concurrent administration of antacids and prednisone: effect on serum levels of prednisolone.
Author(s) -
Tanner AR,
Caffin JA,
Halliday JW,
Powell LW
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00952.x
Subject(s) - antacid , prednisolone , prednisone , cmax , pharmacokinetics , oral administration , radioimmunoassay , medicine , corticosteroid , chemistry , pharmacology , endocrinology
1 Specific radioimmunoassays have been developed for the measurement of prednisolone and prednisone in serum. 2 Serum prednisolone levels have been measured following the administration of prednisone both with and without antacids. 3 There were no significant differences in the values of Cmax (mean +/‐ s.d.) (251 +/‐ 80 ng/ml with, 245 +/‐ 69 ng/ml without antacid), AUC (1430 +/‐ 469 ng ml‐1 h‐1 with, 1406 +/‐ 530 ng ml‐1 h‐1 without antacid) or Tmax (1.6 +/‐ 0.6 h with, 1.6 +/‐ 0.8 h without antacid). 4 Serum prednisone levels were less than 20% of prednisolone levels at all time intervals in the subjects studied. 5 Concurrent antacid administration has no significant effect on serum prednisolone levels attained.