Premium
Plasma cinnarizine levels resulting from oral administration as capsule or tablet formulation investigated by gas‐liquid chromatography.
Author(s) -
Morrison PJ,
Bradbrook ID,
Rogers HJ
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00944.x
Subject(s) - cinnarizine , capsule , chromatography , plasma levels , absorption (acoustics) , pharmacology , chemistry , significant difference , oral administration , pharmacokinetics , plasma concentration , anesthesia , medicine , materials science , botany , composite material , biology
1 A gas chromatographic assay for the estimation of therapeutic concentrations of cinnarizine in plasma is described. 2 Cinnarizine (75 mg) was administered orally to twelve healthy subjects in the form of capsules and tablets on two separate occasions. No difference was found in the plasma levels or absorption of cinnarizine from these formulations. 3 The mean plasma elimination half‐life of cinnarizine was 3.24 h.