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Bioavailability of conventional and slow‐release oxprenolol in fasted and nonfasted individuals.
Author(s) -
Dawes CP,
Kendall MJ,
Welling PG
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00936.x
Subject(s) - bioavailability , oxprenolol , pharmacology , medicine , blood pressure
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow‐release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half‐lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow‐release tablets. 3 Slow‐release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma‐ drug profiles in fasted and nonfasted individuals.