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Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid.
Author(s) -
Bye A,
Lewis Y,
O'Grady J
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00933.x
Subject(s) - aspirin , arachidonic acid , platelet , ingestion , chemistry , platelet aggregation , ex vivo , medicine , pharmacology , biochemistry , in vitro , enzyme
1 The platelet aggregation response to arachidonic acid ex vivo was measured in six volunteers daily before and for 10 days after a single oral dose of 600 mg aspirin. 2 Arachidonic acid induced aggregation of platelets from all subjects before aspirin and aggregation occurred after an interval which varied inversely with the concentration of arachidonic acid. No aggregation occurred for 4 days after aspirin; a reduced response, compared with pre‐aspirin values, was obtained on the 5th, 6th and 8th day. The values on days 7, 9 and 10 were not consistently different from the pre‐aspirin values. In 6 subjects 24 h after aspirin ingestion the addition of 10–25% v/v normal platelets restored the aggregation response. 3 It is concluded that aspirin has an effect on the platelet precursors in the marrow in addition to its effect on circulating platelets.