Premium
Uricosuric properties of diflunisal in man.
Author(s) -
Dresse A,
Fischer P,
Gerard MA,
Tempero KF,
Meisinger MA,
Bolognese JA,
Verhaest L
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00931.x
Subject(s) - diflunisal , uric acid , uricosuric , urine , medicine , chemistry , endocrinology , pharmacology , hyperuricemia
1 The uricosuric effect of diflunisal was studied in eleven normal subjects. 2 Urine and serum uric acid levels were measured and used to assess the effect. 3 Diflunisal caused statistically significant decreases in serum uric acid levels and increases in uric acid clearance at 250 and 375 mg twice daily. 4 Diflunisal taken on an empty stomach caused epigastric discomfort in the high dose group which was obviated when the drug was taken with meals. 5 Diflunisal caused no abnormalities in the measured haematological, urological or biochemical parameters.