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Effects of H1‐ and H2‐receptor blocking agents on histamine‐induced bronchoconstriction in non‐asthmatic subjects.
Author(s) -
Maconochie JG,
Woodings EP,
Richards DA
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00927.x
Subject(s) - bronchoconstriction , cimetidine , histamine , histamine h1 receptor , pharmacology , histamine receptor , histamine h2 receptor , histamine h1 antagonists , medicine , receptor , asthma , antagonist
1 Two studies have been carried out to investigate the effect of H1‐ and H2‐receptor blocking agents on histamine‐induced bronchoconstriction in non‐asthmatic subjects. 2 The H2‐receptor blocker cimetidine administered orally had no effect on histamine‐ induced bronchoconstriction on any of the subjects tested. In three of four subjects, the H1‐receptor blocker, chlorpheniramine given orally, inhibited the effect of the histamine in the lung. 3 The effects of intravenous chlorpheniramine and cimetidine, both alone and in combination, upon histamine‐induced bronchoconstriction, were also studied. Chlorpheniramine inhibited the effect of the histamine and this was significantly dose related. This was not so with cimetidine and there was no evidence that the dose response curve to chlorpheniramine was affected by the additional administration of cimetidine. 4 The results show that histamine‐induced bronchoconstriction in non‐asthmatic subjects is not mediated by H2‐ receptors, but it is likely that H1‐receptors are involved.