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Rate of onset of hypotensive effect of oral labetalol.
Author(s) -
Serlin MJ,
Orme MC,
Maciver M,
Green GJ,
Macnee CM,
Breckenridge AM
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00916.x
Subject(s) - labetalol , blood pressure , medicine , anesthesia , oral administration , pharmacology
1 Labetalol caused a fall in blood pressure within 2 h or oral doses of 100, 200 and 400 mg in six hypertensive patients. 2 This fall which was dose‐related was maximal by 3 h and was sustained when the drug was given in doses of 100 mg 8 hourly, 200 mg 8 hourly and 400 mg 8 hourly. 3 This rapid fall in pressure when labetalol is given by mouth which contrasts to that seen on administration of pure beta‐adrenoceptor blocking agents is a valuable therapeutic property.