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HYPNOTIC EFFICACY OF TEMAZEPAM: A LONG‐TERM SLEEP LABORATORY EVALUATION
Author(s) -
MITLER M.M.,
CARSKADON MARY A.,
PHILLIPS R.L,
STERLING W.R.,
ZARCONE V.P.,
SPIEGEL R.,
GUILLEMINAULT C.,
DEMENT W.C.
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00459.x
Subject(s) - temazepam , hypnotic , anesthesia , medicine , sleep (system call) , population , benzodiazepine , receptor , environmental health , computer science , operating system
1 Temazepam was evaluated in a strictly defined insomniac patient population under sleep laboratory conditions. Two protocols were used: a short‐term (26‐night) and a long‐term (54‐night) protocol evaluated the efficacy of the drug administered at night at 15 mg (short‐term study) and 30 mg (long‐term study), respectively. 2 Temazepam seemed to be both safe and effective at doses of 15 and 30 mg with up to 5 weeks of ingestion. 3 Suppression of slow wave sleep was observed at the high dose, but no suppression of REM sleep, found in studies with other benzodiazepines, was noted. 4 No evidence was found for development of tolerance or rebound effects.