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EFFECTS OF HYPNOTIC AND SLEEP‐INDUCING DRUGS ON OBJECTIVE ASSESSMENTS OF HUMAN PSYCHOMOTOR PERFORMANCE AND SUBJECTIVE APPRAISALS OF SLEEP AND EARLY MORNING BEHAVIOUR
Author(s) -
HINDMARCH I.
Publication year - 1979
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1979.tb00455.x
Subject(s) - temazepam , nitrazepam , hypnotic , insomnia , placebo , morning , sleep induction , anesthesia , medicine , secobarbital , psychomotor learning , sleep (system call) , zopiclone , psychology , diazepam , psychiatry , benzodiazepine , pentobarbital , alternative medicine , cognition , pathology , receptor , computer science , operating system
1 An acute dose comparison against placebo of the effects of nitrazepam 5 mg and temazepam 15 and 30 mg on measures of arousal and performance and on subjective assessment of sleep was carried out in 20 subjects with a history of using night‐time medication for insomnia. 2 Amylobarbitone (100 mg) was included as an active control and each drug was given in hard gelatin capsules. Subjects reported improved sleep with nitrazepam 5 mg and temazepam 30 mg, but there was evidence of impaired performance the next day with temazepam 30 mg. 3 The effect of temazepam 20 mg prepared in the Scherer formulation was compared against placebo in a further ten subjects. The subjects reported improved sleep without evidence of impaired performance the next day.