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Adrenocortical suppression by synthetic corticosteroid drugs: a comparative study of prednisolone and betamethasone.
Author(s) -
Downie WW,
Dixon JS,
Lowe JR,
Rhind VM,
Leatham PA,
Pickup ME
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb04603.x
Subject(s) - betamethasone , prednisolone , corticosteroid , medicine , potency , endocrinology , pharmacology , chemistry , in vitro , biochemistry
1 Single‐dose studies were conducted to investigate the relative potency of prednisolone and betamethasone in suppressing adrenocortical function. 2 Betamethasone produced more profound suppression of plasma cortisol than an equivalent anti‐inflammatory dose of prednisolone.