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Some effects of mianserin on monoamine metabolism in the rat brain.
Author(s) -
Leonard BE
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb04568.x
Subject(s) - mianserin , pharmacology , metabolism , monoamine neurotransmitter , medicine , chemistry , endocrinology , serotonin , receptor
1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5‐hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re‐uptake mechanisms before it can be considered as a potential antidepressant.