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PHARMACOKINETICS OF SUSTAINED RELEASE ASPIRIN
Author(s) -
BROOKS P.M.,
ROBERTS M.S.,
PATEL B.
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01717.x
Subject(s) - pharmacokinetics , aspirin , metoclopramide , pharmacology , medicine , absorption (acoustics) , urinary system , meal , anesthesia , physics , acoustics , vomiting
1 Salivary salicylate concentrations were used to study the pharmacokinetics of a sustained release aspirin (SRA) in normal volunteers. 2 The effect of fasting, food and metoclopramide were studied. 3 Metoclopramide hastens absorption while a heavy meal delays absorption of SRA. 4 The mean urinary recovery of aspirin in all the trials was 608 mg and the different treatments did not significantly alter urinary recovery.