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PHARMACOKINETICS OF VALPROIC ACID AFTER ORAL AND INTRAVENOUS ADMINISTRATION
Author(s) -
PERUCCA E.,
GATTI G.,
FRIGO G.M.,
CREMA A.
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01713.x
Subject(s) - pharmacokinetics , valproic acid , pharmacology , oral administration , medicine , absorption (acoustics) , distribution (mathematics) , serum concentration , carbamazepine , epilepsy , psychiatry , acoustics , mathematical analysis , physics , mathematics
1 The kinetics of sodium valproate (di‐ n ‐propyl‐acetate, Depakine®) have been studied in six healthy volunteers after administration of single oral and intravenous doses (800 mg). 2 Kinetic parameters were similar for both routes of administration. In all subjects absorption was rapid and complete. Half‐lives ranged from 11–15 h. Apparent volumes of distribution were relatively low (0.147 ± 0.0041/kg) and showed little variation amongst individuals. 3 The factors responsible for the poor correlation between dosage and serum levels during chronic treatment and therapeutic implications are discussed.