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Plasma concentrations of diazepam and desmethyldiazepam during chronic diazepam therapy.
Author(s) -
Rutherford DM,
Okoko A,
Tyrer PJ
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01684.x
Subject(s) - diazepam , metabolite , plasma concentration , pharmacology , pharmacokinetics , chemistry , active metabolite , plasma levels , medicine
1 Plasma concentrations of diazepam and its metabolite, desmethyldiazepam, have been measured in both in‐ and out‐patient groups treated with diazepam for periods varying between 1 month and 10 years. 2 The diazepam concentration was directly related to the dose of diazepam ingested and inversely related to the age of the patient. 3 A highly significant relationship was obtained between the concentration of desmethyldiazepam and diazepam. 4 The plasma concentrations of both diazepam and its metabolite were independent of sex, duration fo therapy and patient group.