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Some clinical pharmacological studies with terfenadine, a new antihistamine drug.
Author(s) -
Kulshrestha VK,
Gupta PP,
Turner P,
Wadsworth J
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01677.x
Subject(s) - terfenadine , antihistamine , chlorpheniramine maleate , placebo , medicine , sedation , anesthesia , pharmacology , histamine h1 receptor , antagonist , chemistry , alternative medicine , receptor , pathology , chromatography
1 A double‐blind cross‐over trial between placebo, chlorpheniramine, and terfenadine, a new antihistamine drug, was performed in healthy male volunteers to determine and compare their CNS and autonomic effects. 2 Terfenadine and chlorpheniramine were administered orally in therapeutic doses. 3 In objective tests of critical flicker frequency, pursuit rotor, reaction time, salivary volume and pupillary diameter, no statistically significant difference was observed between the treatments. 4 On analogue rating scales, chlorpheniramine produced a statistically significant (P less than 0.05) degree of sedation and impaired concentration as compared to placebo and terfenadine. 5 The results obtained in analogue rating scales were not normally distributed and, therefore, use of non‐parametric statistical methods for analysis of such data is strongly advocated.