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The use of dobutamine in myocardial infarction for reversal of the cardiodepressive effect of metoprolol.
Author(s) -
Waagstein F,
Malek I,
Hjalmarson AC
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01666.x
Subject(s) - metoprolol , myocardial infarction , dobutamine , cardiology , medicine , adrenergic beta antagonists , anesthesia , propranolol , hemodynamics
1 Ten patients with acute myocardial infarction were infused dobutamine in increasing doses up to 15 microgram kg‐1 min‐1. 2 Metoprolol (total dose 15 mg) was then given intravenously to nine of these patients and the beta‐adrenoceptor against effects produced by dobutamine were effectively reversed. 3 Nine patients with acute myocardial infarction pretreated with metoprolol (15 mg) were infused dobutamine 15 microgram kg‐1 min‐1 for 10 min. This resulted in effective reversal of the beta‐adrenoceptor antagonist effects induced by metoprolol, without the occurrence of serious arrhythmias or other unwanted effects. 4 Dobutamine may be valuable in counteracting any undesirable cardiodepressive effects of beta‐adrenergic receptor blocking drugs (especially the cardioselective agents) in patients with acute myocardial infarction.