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(+)‐Propranolol clearance, an estimation of hepatic blood flow in man.
Author(s) -
Weiss YA,
Safar ME,
Lehner JP,
Levenson JA,
Simon A,
Alexandre JM
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01655.x
Subject(s) - propranolol , extraction ratio , blood flow , basal (medicine) , medicine , endocrinology , renal function , renal blood flow , chemistry , extraction (chemistry) , chromatography , insulin
1 Hepatic blood flow was determined before and during (+)‐ and (+/‐)‐ propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/‐)‐propranolol administration and remained unchanged during (+)‐propranolol administration. 3 Hepatic extraction ratio was 74 +/− 1% (+/‐)‐ propranolol and 79 +/− 2% for (+)‐propranolol. 4 Total propranolol clearances were determined during the steady‐state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)‐propranolol clearance. The slope of the curve was 1.05 +/− 0.27. 5 The result implies that the total clearance of (+)‐propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function.