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A thermographic assessment of three intra‐articular prednisolone analogues given in rheumatoid synovitis.
Author(s) -
Esselinckx W,
Bacon PA,
Ring EF,
Crooke D,
Collins AJ,
Demottaz D
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01653.x
Subject(s) - prednisolone , synovitis , rheumatoid arthritis , medicine , dermatology
1 Three intra‐articular prednisolone analogues have been studied in a group of forty‐six rheumatoid arthritic subjects. Each compound was tested at 50 mg and 100 mg dose over 3 weeks. 2 The anti‐inflammatory effect was assessed by quantitative thermography. Systemic escape of the drug was monitored by plasma prednisolone and cortisol levels. 3 Both the systemic escape from the joint and the duration of effect on injected and uninjected knees were related to drug solubility. 4 Depression of plasma cortisol occurred with all three preparations and was most prolonged with the long‐acting preparation. 5 Increasing the dose from 50 mg to 100 mg increased the antiflammatory effect only with the soluble acetate preparation.