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The inhibiton of adrenergically provoked renin release by salbutamol in man.
Author(s) -
Wiggins R,
Davies R,
Basar I,
Slater JD
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01626.x
Subject(s) - salbutamol , isoprenaline , endocrinology , medicine , renin–angiotensin system , agonist , stimulation , chemistry , antagonist , adrenergic receptor , terbutaline , receptor , blood pressure , asthma
1 The beta‐adrenoceptor agonist salbutamol is shown to have antagonist properties by its effect on adrenergically provoked renin release in normal people. 2 It significantly reduces the rate of renin secretion provoked by either endogenous (85 dregrees head‐up tilt) or exogenous (isoprenaline infusion) adrenergic stimulation. 3 Because renin is relatively simple to measure, and because in acute studies its release is relatively uninfluenced by the vagaries of direct and reflex cardiovascular effects, we suggest that, in the characterization of drugs which act on adrenergic beta‐receptors, an assessment of their effects on renin release would be useful.