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Amitriptyline‐ and mianserin‐induced changes in acquisition of paired‐ association learning‐task.
Author(s) -
Liljequist R,
Seppala T,
Mattila MJ
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01616.x
Subject(s) - mianserin , amitriptyline , association (psychology) , task (project management) , medicine , psychology , pharmacology , neuroscience , antidepressant , psychotherapist , management , hippocampus , economics
1 The double‐blind study on twenty healthy students was an attempt at assessing the effects of 2‐week's treatment with amitriptyline (25 mg three times a day) and mianserin (10 mg three times a day), each alone or separatively inbibed with alcohol (0.5 g/kg) on the immediate memory and on the acquisition of a paired‐association learning‐task. 2 Amitriptyline impaired both the short‐term memory‐span and acquisition, and alcohol potentiated these effects. The action of mianserin did not deviate significantly from that of the placebo, and it also failed to interact with alcohol. 3 It is concluded that the decrement in learning capacity, that occurs after the 2‐week's treatment with therapeutic doses of amitriptyline, reflects changes in both the intrinsic and the regulatory mechanisms of learning.