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Comparison of atenolol and oxprenolol in patients with angina or hypertension and co‐existent chronic airways obstruction.
Author(s) -
Perks WH,
Chatterjee SS,
Croxson RS,
Cruickshank JM
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb01608.x
Subject(s) - oxprenolol , atenolol , bronchodilatation , medicine , isoprenaline , anesthesia , cardiology , salbutamol , asthma , blood pressure , propranolol , stimulation
1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with “fixed” airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with “labile” airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.