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The effect on myocardial contractility of a new beta‐adrenergic receptor blocking drug, penbutolol.
Author(s) -
Sapru RP,
Sharma PL
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb00875.x
Subject(s) - inotrope , contractility , propranolol , medicine , adrenergic receptor , blocking (statistics) , cardiology , pharmacology , receptor , mathematics , statistics
1 The inotropic effect of penbutolol, a new beta‐adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp‐dt/11 T] as well as the slope of the regression line relating LV dp/dt to LVED during incremental pacing. 3 Penbutolol was found to have a significant negative inotropic effect of an order similar to that of propranolol in the respective doses studied.