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Comparison of the effect of drugs upon some commonly used measures of bowel transit time.
Author(s) -
Rogers HJ,
House FR,
Morrison PJ,
Bradbrook ID
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb00872.x
Subject(s) - senna , transit time , placebo , cathartic , statistical analysis , medicine , transit (satellite) , pharmacology , traditional medicine , statistics , public transport , pathology , mathematics , engineering , alternative medicine , transport engineering , law , political science
1 To study the effect of drugs on methods of assessment of gut transit time a double‐blind study of the effect of single doses of placebo, oxyphenisatin, anthracene purgatives, (+)‐norpseudoephedrine and a combined preparation of (+)‐norpseudophedrine and senna was carried out in ten normal volunteers. Gut transit time was assessed by dye and radio‐opaque marker methods. 2 It was possible to demonstrate the effect of the anthracenes but not oxyphenisatin on gut transit time. 3 More sophisticated statistical techniques were required to demonstrate the retarding effect of the sympathomimetic amine and its reversal by senna. 4 Statistical analysis shows that assessment of intestinal transit time by dye or pellet methods gives identical information.