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Digoxin compliance in patients from general practice.
Author(s) -
Johnston GD,
McDevitt DG
Publication year - 1978
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1978.tb00861.x
Subject(s) - digoxin , medicine , compliance (psychology) , plasma concentration , anesthesia , plasma levels , drug , pharmacology , heart failure , psychology , social psychology
1. Compliance with digoxin therapy has been assessed in a group of fifty patients receiving the drug in general practice but not attending hospital. 2. Compliance was estimated by comparing plasma digoxin concentrations before and after a 10 day period of measured digoxin consumption and by tablet counting. 3. Twelve patients had plasma concentrations which increased by more than 0.4 ng/ml during monitored intake and eight other patients took less than 80% of their tablets. These twenty patients were considered non‐compliant. 4. A further three patients in whom plasma digoxin levels were zero when first seen but increased substantially during the run‐in period were also adjudged non‐ compliant. 5. Non‐compliance with prescribed digoxin dosage occurred, therefore, in 46% of the patients studied.