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Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance.
Author(s) -
Hindmarch I.,
Parrott AC
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb05747.x
Subject(s) - nomifensine , imipramine , flicker fusion threshold , placebo , crossover study , volunteer , medicine , digit symbol substitution test , anesthesia , psychomotor learning , psychology , psychiatry , flicker , cognition , computer science , alternative medicine , dopaminergic , pathology , agronomy , biology , dopamine , operating system
1. Nine normal subjects volunteered to participate in a randomized single‐blind crossover study of nomifensine 75 mg and two comparators, imipramine 75 mg and placebo. 2. Each volunteer received placebo for 3 d, then the first test drug for 4 days. This sequence was repeated twice more, so that each subject received each comparator. All medication was taken three times daily. 3. Assessments were made on days 3, 5 and 7 of each sequence, and consisted of a Sleep Evaluation Questionnaire, a test of Critical Flicker Fusion and a measure of Complex Reaction Time (CRT). 4. There were no significant differences in the CRT. There was a significant increase in critical flicker fusion with nomifensine. 5. Although both nomifensine and imipramine disturbed the quality of sleep, only imipramine produced a hangover.