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A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.
Author(s) -
Chamberlain J.,
Hill HM
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb05737.x
Subject(s) - nomifensine , chromatography , conjugate , clearance , chemistry , microgram , medicine , mathematics , urology , biochemistry , mathematical analysis , dopaminergic , in vitro , dopamine
1. A rapid simple gas chromatographic technique for determining nomifensine in plasma is described. 2. Nomifensine is rapidly absorbed after oral administration to man. 3. Following a 100‐mg dose, peak levels of an acid‐labile conjugate of 2–3 microgram/ml are reached about 1.5 h after administration. 4. The conjugate is cleared with a half‐life of between 1 and 2 hours.