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Diflunisal: efficacy in postoperative pain.
Author(s) -
Winzum C,
Rodda B
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb04513.x
Subject(s) - diflunisal , medicine , placebo , anesthesia , adverse effect , tenoxicam , surgery , clinical trial , randomized controlled trial , piroxicam , pharmacology , alternative medicine , pathology
1. Seven hundred and forty patients complaining of pain after oral or orthopaedic surgery or episiotomy were studied in five single dose or short‐term double‐blind, controlled, randomized studies comparing efficacy and safety of diflunisal with that of acetylsalicylic acid, glafenin or placebo. 2. Diflunisal was found to be effective in relieving postoperative pain in 75‐85% of patients. A twice day dosage schedule seems to be clinically adequate, 375 mg twice daily proving to be equally effective as glafenin 200 mg three times daily. No serious drug‐related clinical or laboratory adverse experiences were encountered in any of the five studies.