Premium
Plasma prednisolone levels from enteric and non‐enteric coated tablets estimated by an original technique.
Author(s) -
Morrison PJ,
Bradbrook ID,
Rogers HJ
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00792.x
Subject(s) - enteric coated , prednisolone , enteric coating , bioavailability , enteric fever , radioimmunoassay , chromatography , absorption (acoustics) , chemistry , medicine , pharmacology , dosage form , materials science , pathology , composite material , typhoid fever
1 A quantitative thin layer chromatographic technique for the estimation of plasma prednisolone levels has been devised with a minimum level of estimation of 10 ng/ml. 2 A comparative study of the absorption of 5 and 10 mg prednisolone from enteric and non‐enteric coated tablets (5 mg) was carried out in healthy subjects. 3 Mean plasma half‐life and peak plasma concentrations obtained from the non‐ enteric coated preparation agree well with previous studies in normal subjects reported by other investigators using competitive protein binding or radioimmunoassay techniques. Intersubject variability in bioavailability was noted. 4 Enteric coating increased the lag time before prednisolone appeared in the blood but did not alter the bioavailability of prednisolone compared to the equivalent dose of the non‐enteric coated tablet.