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Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease.
Author(s) -
Hutton I,
Hillis WS,
Langhan CE,
Conely JM,
Lawrie TD
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00778.x
Subject(s) - medicine , ventricle , cardiology , inotrope , myocardial infarction , chronotropic , angina , contractility , heart rate , blood pressure
1 The chronotropic and inotropic properties of U.K. 14275, a phosphodiesterase inhibitor were assessed in patients with coronary heart disease. 2 Left ventricular function was assessed in eight patients with acute myocardial infarction using the non‐invasive measurement of systolic time intervals. 3 Twelve patients with angina pectoris were studied during diagnostic coronary arteriography. Left ventricular function was assessed using a high fidelity catheter tipped transducer in the left ventricle. 4 In both groups of patients U.K. 14275 infused intravenously in doses of 32, 64, 128 and 256 microgram kg‐1 bodyweight min‐1 enhanced the contractile state of the left ventricle without altering the heart rate.