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Once daily treatment of mild to moderate hypertension with xipamid: a controlled study.
Author(s) -
Weber JC,
Bird H,
Cosh J,
Davies PS,
Dixon AS,
Lister J,
Petts HV,
Prichard BN,
Raftery EB
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00713.x
Subject(s) - placebo , medicine , blood pressure , crossover study , clinical trial , essential hypertension , pharmacology , pathology , alternative medicine
A double‐blind, placebo controlled, crossover trial of 20 and 40 mg of xipamid once daily in the treatment of mild to moderate hypertension is reported and some of the difficulties and pitfalls of multicentre trials of this type are described. 2 Both doses were significantly more effective in reducing the blood pressure than the placebo and neither was superior to the other. Both produced some potassium loss. Xipamid acted for at least 22 h and was effective in up to 83% of the patients. 3 Further trials are suggested to investigate the activity of a lower dose than 20 mg.