Premium
Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.
Author(s) -
Aronson JK,
GrahameSmith DG
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00698.x
Subject(s) - digoxin , volume of distribution , medicine , pharmacology , distribution (mathematics) , ic50 , cardiology , chemistry , pharmacokinetics , in vitro , mathematics , heart failure , biochemistry , mathematical analysis
1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre‐treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre‐treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed.