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Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response.
Author(s) -
Aronson JK,
GrahameSmith DG,
Hallis KF,
Hibble A,
Wigley F
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00697.x
Subject(s) - digoxin , atrial fibrillation , in vitro , pharmacology , medicine , therapeutic index , plasma concentration , endocrinology , chemistry , cardiology , heart failure , biochemistry , drug
1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre‐treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.