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The effect of dipyridamole on platelet function: correlation with blood levels in man.
Author(s) -
Rajah SM,
Crow MJ,
Penny AF,
Ahmad R,
Watson DA
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00683.x
Subject(s) - dipyridamole , platelet , platelet adhesiveness , medicine , pharmacology , platelet adhesion , platelet factor 4 , warfarin , platelet aggregation , atrial fibrillation
1 The effect on platelet functions of dipyridamole (a pyrimido‐ pyrimidine compound) was compared with a control group of patients taking warfarin. 2 Adhesion, aggregation and platelet factor 4 availability showed a significant decrease in the dypyridamole group. 3 Aggregation and platelet factor 4 showed a significant correlation with blood dipyridamole level. 4 Adhesion, aggregation and platelet factor 4 were reduced below the lower limit of normal at blood dipyridamole levels above 3.5 micronmol/1.