Premium
The effect of carbidopa administration on urinary sodium excretion in man. Is dopamine an intrarenal natriuretic hormone?
Author(s) -
Ball SG,
Lee MR
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00681.x
Subject(s) - carbidopa , endocrinology , dopamine , excretion , medicine , chemistry , urinary system , natriuresis , hormone , sodium , levodopa , disease , parkinson's disease , organic chemistry
1 Carbidopa, a known inhibitor of the peripheral conversion of dopa to dopamine, was given to six normal volunteers to examine the effect of interference with dopamine synthesis on urinary sodium excretion. 2 On the first day of administration, carbidopa caused a significant fall not only in urinary dopamine excretion (P less than 0.01) but also in urinary sodium excretion (P less than 0.05). 3 A highly significant correlation was also found between mean sodium excretion and mean dopamine excretion in the days prior to and during carbidopa administration (r = 0.617, P less than 0.001; 4 = 0.764, P less than 0.001 respectively). 4 The significance of these findings is discussed and it is proposed that dopamine may be an important intrarenal natriuretic hormone.