Premium
Changes in reaction time and drug plasma concentrations after nitrazepam and glutethimide.
Author(s) -
Curry SH,
Whelpton R,
Scott DF
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00680.x
Subject(s) - glutethimide , nitrazepam , plasma concentration , placebo , drug , chemistry , pharmacology , medicine , diazepam , alternative medicine , pathology
1 The effects of nitrazepam, glutethimide and placebo were assessed in a double‐blind cross‐over study with five healthy human subjects, using reaction time, and relating changes to drug concentrations in the plasma. 2 After glutethimide in all five subjects, and after nitrazepam in four subjects, larger doses led to higher concentrations in plasma and to greater changes in reaction time; one subject displayed the higher nitrazepam concentrations and the greater effect following the smaller dose. 3 The relationship between change in reaction time and concentration appeared to be mainly a within‐subject dose‐effect relationship, with the peak concentration in plasma as the ‘dose’ and the area under the reaction time curve as the effect.