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COMPARISON OF THE BRONCHODILATOR EFFECTS OF SALBUTAMOL INHALED AS A DRY POWDER AND BY CONVENTIONAL PRESSURISED AEROSOL
Author(s) -
DUNCAN D.,
PATERSON I.C.,
HARRIS D.,
CROMPTON G.K.
Publication year - 1977
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1977.tb00428.x
Subject(s) - salbutamol , bronchodilator , inhalation , placebo , dry powder inhaler , aerosol , asthma , medicine , anesthesia , chemistry , inhaler , alternative medicine , organic chemistry , pathology
1 A double‐blind placebo controlled comparison of the bronchodilator effects of salbutamol inhaled as a dry powder and by conventional pressurized aerosol was carried out in 20 patients with chronic bronchial asthma. 2 No significant difference in the bronchodilator response between 400 μg and 600 μg of dry powder and 200 μg from the aerosol was detected. 3 Even with the highest dose of 600 μg dry powder salbutamol no subjective or objective side‐effects were observed and the inhalation of salbutamol in a lactose base was well tolerated by all the patients.