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INCREASED PLATELET AGGREGATION IN PATIENTS RECEIVING CHLORPROMAZINE: RESPONSES TO 5‐HYDROXYTRYPTAMINE, DOPAMINE AND N‐DIMETHYL DOPAMINE
Author(s) -
BOULLIN D.J.,
GRIMES R.P.J.
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb04889.x
Subject(s) - dopamine , chlorpromazine , platelet , pharmacology , medicine , serotonin , platelet aggregation , chemistry , anesthesia , receptor
1 Platelet aggregation responses to 5‐HT, dopamine, N‐dimethyl dopamine and adenosine diphosphate were compared in normal subjects and patients treated with chlorpromazine (CPZ) for longer than 6 months. 2 We confirmed our previous finding that 5‐HT induced aggregation is enhanced in CPZ treated patients. 3 Increased aggregation responses were also observed with dopamine and N‐dimethyl dopamine. 4 Quantitative comparisons of aggregation rates and total changes in optical density of platelet rich plasma relative to adenosine diphosphate showed significant increases with 5‐HT, dopamine and N‐dimethyl dopamine. 5 Implication of dopaminergic mechanisms in the central effects of phenothiazines suggests that changes in dopamine induced aggregation responses may be useful in attempting correlations of clinical and pharmacological effects.