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THE RADIOIMMUNOASSAY OF TRICYCLIC ANTIDEPRESSANTS
Author(s) -
AHERNE G.W.,
PIALL E.M.,
MARKS V.
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb04875.x
Subject(s) - radioimmunoassay , tricyclic , medicine , pharmacology
1 An antiserum to nortriptyline has been produced in a sheep against a nortriptyline‐bovine serum albumin conjugate. The conjugate was prepared using the reagent N‐(4‐bromobutyl) phthalimide followed by a carbodiimide reaction to link the hapten to the carrier protein. 2 The antibodies produced were shown to be specific for the tricyclic group of drugs. 3 The sensitivity of the radioimmunoassay developed is currently limited by the lack of a high specific activity label. The possibilities of developing a radioimmunoassay for nortriptyline in plasma are discussed.