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AN ELECTROENCEPHALOGRAPHIC INVESTIGATION OF SHORT‐TERM EFFECTS OF THREE HYPOTHALAMIC HORMONES (TRH, LH/FSH‐RH, GH‐RIH) IN NORMAL SUBJECTS
Author(s) -
ASHTON HEATHER,
MILLMAN J. E.,
TELFORD ROSEMARY,
THOMPSON J. W.,
DAVIES T. F.,
HALL R.
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb04871.x
Subject(s) - endocrinology , medicine , hormone , follicle stimulating hormone , luteinizing hormone
1 Three hypothalamic regulatory hormones, thyrotrophin‐releasing hormone (TRH), luteinizing hormone/follicle‐stimulating hormone‐releasing hormone (LH/FSH—RH) and growth hormone‐release inhibiting hormone (GH—RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects. 2 TRH was given as a 10 ml infusion of 600 μg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude. 3 LH/FSH—RH was given in a dose of 200 μg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects. 4 GH—RIH was given as a 10 ml infusion of 250 μg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.